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The first functions of Ca Given the above data concerning environmental and cell concentrations in Section 4, Ca was clearly expelled from cells as a very early necessity to avoid precipitations, for example, of RNA and DNA, and competition with the more effective Lewis acid, Mg2, in the cytoplasm, the only initial internal compartment.
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Barth, J. 290 Principles of Central Nervous System Pharmacology From cortex A NMDA-R Dopamine receptor Natural reward From VTA Dopamine NAc Sensory cues (action potential) B Sensory cues C (action potential) D Stress Relapse mechanisms Ca2 Ca2 Na Na Glutamate non-NMDA-R Ca2 Na Neuroadaptation Time x Dose Dependence Increase in glutamate receptors Increase in structural proteins CaMKII Gene transcription Reward learning CaMKII Drug of abuse NAc Ca2 Na 123 Ca2 Na Cellular NAc excitation Relapse Ca2 Na Cellular NAc excitation Relapse Drug re-exposure Ca2 Na Cellular excitation Relapse FIGURE 18-2.
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