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At least for murine DCs in vitro, it appears that IL-4 and IL-13 can synergize with GM-CSF to activate STAT-6 and bring about DC maturation (upregulation of MCH II and co-stimulatory mole- cules) via IL-4R type II, while IL12p70 in response to microbial products is medi- ated by IL-4 (but not IL-13), acting through IL-4R type I and Jak3 [358].

(4-82), 5-year survival for meta- static colon cancer is dismal, 9, in contrast to 90 5-year survival for patients with localized disease (Dukes A). Injuries relating to the pelvis, knee, ankle and foot will not be discussed in detail as these areas are covered in their specific chapters.

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